@article{bibcite_203491,
  keywords = {3D chromosomal organization, CP: Immunology, CP: molecular biology, ChIP-seq, Hi-C, T cells, Treg cells, gene regulation, interchromosomal interactions, metadomains, metaloops, promoter-enhancer interactions},
  author = {Gabriel Dolsten and Zhong-Min Wang and Xiao Huang and Susie Song and Michael Wilson and Xin Bing and Wenfan Ke and Thomas Cafiero and Amy Nelson and Sebastian Fernando and Alexander Ploss and Paul Schedl and Michael Levine and Aaron Viny and Alexander Rudensky and Yuri Pritykin},
  title = {Metadomain and metaloop genome interactions in mammalian T cells.},
  abstract = {<p>Recent studies have advanced understanding of chromosomal organization and its role in gene regulation, yet most analyses focus on short-range interactions (\&lt;2 Mb), limiting insight into broader architecture. The relationships between topologically associating domains (TADs), sub-TAD loops, cross-TAD interactions, and chromosomal compartmentalization remain poorly understood. Here, using high-resolution Hi-C analysis, we identify extensive multi-megabase and interchromosomal interactions (metaloops) in T lymphocytes that organize into meta-TAD associations (metadomains). These metaloops connect distal promoters and regulatory elements of genes functionally important in T cells, including Ctla4, Ikzf2, Il2ra, Ets1, and Foxo1. Reanalysis of mouse and human datasets confirms their reproducibility and dependence on superenhancers. Genome-wide clustering reveals three distinct interchromosomal hubs, including a superenhancer-enriched hub linked to T cell-specific gene activation. Integrative analysis of regulatory genomics data identifies factors associated with short- versus long-range interactions. This study introduces a broadly applicable computational framework and reveals features of T cell genome organization.</p>},
  year = {2026},
  journal = {Cell reports},
  volume = {45},
  pages = {117341},
  month = {05/2026},
  issn = {2211-1247},
  doi = {10.1016/j.celrep.2026.117341},
  language = {eng},
}