@article{85361, author = {von Markus Schaewen and Gabriela Hrebikova and Alexander Ploss}, title = {Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.}, abstract = { Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter. }, year = {2016}, journal = {Methods Mol Biol}, volume = {1438}, pages = {79-101}, issn = {1940-6029}, doi = {10.1007/978-1-4939-3661-8_5}, language = {eng}, }