@article{85481,
  keywords = {Animals, Humans, Sequence Analysis, DNA, Real-Time Polymerase Chain Reaction, Mice, Mice, Transgenic, DNA Primers, DNA, Viral, HIV-1, Antibodies, Neutralizing, Dependovirus, Viral Load, Anti-Retroviral Agents, Drug Therapy, Combination, HIV Infections, Immunotherapy},
  author = {Joshua Horwitz and Ariel Halper-Stromberg and Hugo Mouquet and Alexander Gitlin and Anna Tretiakova and Thomas Eisenreich and Marine Malbec and Sophia Gravemann and Eva Billerbeck and Marcus Dorner and Hildegard B{\"u}ning and Olivier Schwartz and Elena Knops and Rolf Kaiser and Michael Seaman and James Wilson and Charles Rice and Alexander Ploss and Pamela Bjorkman and Florian Klein and Michel Nussenzweig},
  title = {HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.},
  abstract = {<p>Effective control of HIV-1 infection in humans is achieved using combinations of antiretroviral therapy (ART) drugs. In humanized mice (hu-mice), control of viremia can be achieved using either ART or by immunotherapy using combinations of broadly neutralizing antibodies (bNAbs). Here we show that treatment of HIV-1-infected hu-mice with a combination of three highly potent bNAbs not only resulted in complete viremic control but also led to a reduction in cell-associated HIV-1 DNA. Moreover, lowering the initial viral load by coadministration of ART and immunotherapy enabled prolonged viremic control by a single bNAb after ART was withdrawn. Similarly, a single injection of adeno-associated virus directing expression of one bNAb produced durable viremic control after ART was terminated. We conclude that immunotherapy reduces plasma viral load and cell-associated HIV-1 DNA and that decreasing the initial viral load enables single bNAbs to control viremia in hu-mice.</p>
},
  year = {2013},
  journal = {Proc Natl Acad Sci U S A},
  volume = {110},
  pages = {16538-43},
  month = {10/2013},
  issn = {1091-6490},
  doi = {10.1073/pnas.1315295110},
  language = {eng},
}