@article{85536,
  keywords = {Animals, Humans, Time Factors, Disease Models, Animal, Mice, Antibodies, Monoclonal, HIV-1, Antibodies, Neutralizing, HIV Antibodies, Mice, Inbred NOD, Viral Load, HIV Infections, Antibody Specificity, Half-Life, Immunization, Passive},
  author = {Florian Klein and Ariel Halper-Stromberg and Joshua Horwitz and Henning Gruell and Johannes Scheid and Stylianos Bournazos and Hugo Mouquet and Linda Spatz and Ron Diskin and Alexander Abadir and Trinity Zang and Marcus Dorner and Eva Billerbeck and Rachael Labitt and Christian Gaebler and Paola Marcovecchio and Reha-Baris Incesu and Thomas Eisenreich and Paul Bieniasz and Michael Seaman and Pamela Bjorkman and Jeffrey Ravetch and Alexander Ploss and Michel Nussenzweig},
  title = {HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.},
  abstract = {<p>Human antibodies to human immunodeficiency virus-1 (HIV-1) can neutralize a broad range of viral isolates in vitro and protect non-human primates against infection. Previous work showed that antibodies exert selective pressure on the virus but escape variants emerge within a short period of time. However, these experiments were performed before the recent discovery of more potent anti-HIV-1 antibodies and their improvement by structure-based design. Here we re-examine passive antibody transfer as a therapeutic modality in HIV-1-infected humanized mice. Although HIV-1 can escape from antibody monotherapy, combinations of broadly neutralizing antibodies can effectively control HIV-1 infection and suppress viral load to levels below detection. Moreover, in contrast to antiretroviral therapy, the longer half-life of antibodies led to control of viraemia for an average of 60 days after cessation of therapy. Thus, combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV-1-infected individuals.</p>
},
  year = {2012},
  journal = {Nature},
  volume = {492},
  pages = {118-22},
  month = {12/2012},
  issn = {1476-4687},
  doi = {10.1038/nature11604},
  language = {eng},
}