@article{85541,
  keywords = {Animals, Humans, Disease Models, Animal, Mice, Mice, Transgenic, Macaca, Virus Internalization, Antibodies, Viral, HIV-1, Antibodies, Neutralizing, HIV Infections},
  author = {John Pietzsch and Henning Gruell and Stylianos Bournazos and Bridget Donovan and Florian Klein and Ron Diskin and Michael Seaman and Pamela Bjorkman and Jeffrey Ravetch and Alexander Ploss and Michel Nussenzweig},
  title = {A mouse model for HIV-1 entry.},
  abstract = {<p>Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody{\textquoteright}s ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions.</p>
},
  year = {2012},
  journal = {Proc Natl Acad Sci U S A},
  volume = {109},
  pages = {15859-64},
  month = {09/2012},
  issn = {1091-6490},
  doi = {10.1073/pnas.1213409109},
  language = {eng},
}