@article{85576,
  keywords = {Animals, Humans, Virus Internalization, Hepatitis C, Hepacivirus},
  author = {Alexander Ploss and Matthew Evans},
  title = {Hepatitis C virus host cell entry.},
  abstract = {<p>The hepatitis C virus (HCV) is a major medical problem with at least 130 million infected individuals worldwide. Over the last decade multiple host factors required for HCV cell entry have been identified, but a detailed understanding of their mechanistic interplay remains elusive. Nonetheless, recent advances in defining species-specific barriers of HCV transmission have allowed the identification of a minimal set of entry factors that are required for HCV infection of rodent cells and has culminated in an animal model that recapitulates HCV entry in vivo. A detailed understanding of the viral uptake pathway is imperative to define new drug targets allowing for more effective intervention against this devastating disease.</p>
},
  year = {2012},
  journal = {Curr Opin Virol},
  volume = {2},
  pages = {14-9},
  month = {02/2012},
  issn = {1879-6265},
  doi = {10.1016/j.coviro.2011.12.007},
  language = {eng},
}