@article{85671, keywords = {Animals, Humans, Biomedical Research, Disease Models, Animal, Mice, Communicable Diseases}, author = {Nicolas Legrand and Alexander Ploss and Rudi Balling and Pablo Becker and Chiara Borsotti and Nicolas Brezillon and Jennifer Debarry and de Ype Jong and Hongkui Deng and James Di Santo and Stephanie Eisenbarth and Elizabeth Eynon and Richard Flavell and Carlos Guzman and Nicholas Huntington and Dina Kremsdorf and Michael Manns and Markus Manz and Jean-Jacques Mention and Michael Ott and Chozhavendan Rathinam and Charles Rice and Anthony Rongvaux and Sean Stevens and Hergen Spits and H{\'e}l{\`e}ne Strick-Marchand and Hitoshi Takizawa and van Anja Lent and Chengyan Wang and Kees Weijer and Tim Willinger and Patrick Ziegler}, title = {Humanized mice for modeling human infectious disease: challenges, progress, and outlook.}, abstract = {

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

}, year = {2009}, journal = {Cell Host Microbe}, volume = {6}, pages = {5-9}, month = {07/2009}, issn = {1934-6069}, doi = {10.1016/j.chom.2009.06.006}, language = {eng}, }