@article{85706,
  keywords = {Animals, Mice, Mice, Transgenic, Cell Differentiation, src-Family Kinases, Killer Cells, Natural, T-Lymphocytes, Proto-Oncogene Proteins, Thymus Gland, Antigens, CD1, Antigens, CD1d, Proto-Oncogene Proteins c-fyn, Receptors, Antigen, T-Cell},
  author = {Tao Dao and Donglin Guo and Alexander Ploss and Amy Stolzer and Carolyn Saylor and Tamar Boursalian and Jin Seon Im and Derek Sant{\textquoteright}Angelo},
  title = {Development of CD1d-restricted NKT cells in the mouse thymus.},
  abstract = {<p>Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4(+)CD8(+) stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations.</p>
},
  year = {2004},
  journal = {Eur J Immunol},
  volume = {34},
  pages = {3542-52},
  month = {12/2004},
  issn = {0014-2980},
  doi = {10.1002/eji.200425546},
  language = {eng},
}