@article{85721,
  keywords = {Animals, Biomarkers, Mice, Mice, Inbred C57BL, Female, Peptide Fragments, Cell Division, Heat-Shock Proteins, Mice, Transgenic, Cell Survival, Mice, Inbred BALB C, T-Lymphocyte Subsets, Immunologic Memory, Listeria monocytogenes, Listeriosis, Lymphocyte Activation, H-2 Antigens, Histocompatibility Antigens Class I, Immunization, Immunization, Secondary, T-Lymphocytes, Cytotoxic, Antigens, Bacterial, Bacterial Toxins, Hemolysin Proteins},
  author = {Kristen Kerksiek and Alexander Ploss and Ingrid Leiner and Dirk Busch and Eric Pamer},
  title = {H2-M3-restricted memory T cells: persistence and activation without expansion.},
  abstract = {<p>H2-M3-restricted T cells respond more rapidly to primary Listeria monocytogenes infection than conventional MHC class Ia-restricted T cells. Reinfection with L. monocytogenes, while inducing explosive proliferation of H2-K(d)-restricted T cells, does not stimulate significant expansion of H2-M3-restricted CTL. These disparate responses to reinfection are apparent within 5 days of primary L. monocytogenes infection. However, H2-M3-restricted memory T cells are generated, and are indistinguishable from classically restricted T cells in terms of cell surface memory markers and longevity. Early responses of H2-M3- and H2-K(d)-restricted memory T cells to reinfection are similar, with increases in size and expression of activation markers. Interestingly, priming of H2-M3-restricted T cells with an L. monocytogenes-derived N-formyl peptide plus anti-CD40 generates memory T cells that expand upon re-exposure to Ag during L. monocytogenes infection. Our data indicate that disparate H2-M3- and MHC class Ia-restricted memory T cell responses reflect intrinsic differences between these T cell populations. Although distinct proliferative programs appear to be hardwired in these populations during primary L. monocytogenes infection, under different inflammatory circumstances M3-restricted T cell populations can maintain the ability to expand upon re-exposure to Ag.</p>
},
  year = {2003},
  journal = {J Immunol},
  volume = {170},
  pages = {1862-9},
  month = {02/2003},
  issn = {0022-1767},
  language = {eng},
}