In this paper, Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses, Florian and colleagues measure the immune response to yellow fever vaccine in humanized mice. This work provides new evidence that humanized mouse models share similarities to humans in their immune responses, and supports their value as a compelling model to study disease pathogenesis. This work was also been featured The Research at Princeton Blog. We thank the Shalek Lab at MIT for their collaboration on this project.

Source of image: https://blogs.princeton.edu/research/2018/11/28/vaccine-signatures-in-humanized-mice-point-to-better-understanding-of-infectious-diseases/