Humanized mice for modeling human infectious disease: challenges, progress, and outlook.

Author

Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, de Ype Jong, Hongkui Deng, James Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard Flavell, Carlos Guzman, Nicholas Huntington, Dina Kremsdorf, Michael Manns, Markus Manz, Jean-Jacques Mention, Michael Ott, Chozhavendan Rathinam, Charles Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, van Anja Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler

Publication Year

2009

Type

Journal Article

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

Keywords

Animals, Humans, Biomedical Research, Disease Models, Animal, Mice, Communicable Diseases

Journal

Cell Host Microbe

Volume

Issue

Pages

5-9

Date Published

07/2009

ISSN Number

1934-6069

DOI

10.1016/j.chom.2009.06.006

Alternate Journal

Cell Host Microbe

PMID

19616761